CATSPER calcium channels in human spermatozoa and their role in responsiveness to progesterone (P)
نویسندگان
چکیده
منابع مشابه
The mystery is solved--CatSper is the principal calcium channel activated by progesterone in human spermatozoa.
A remarkable advance in sperm physiology has recently been published in Nature. Two groups using patch clamping techniques on human sperm have solved a mystery about the sperm cell that has puzzled both andrologists and those involved in nongenomic cellular signalling for over 20 years. In these papers, Lishko and Strunker independently demonstrate that the universal characteristic effect of pr...
متن کاملRole of Calcium and Calcium Channels in Progesterone Induced Acrosome Reaction in Caprine Spermatozoa
There are several physiological and pharmacological evidences indicating that opening of voltage dependent Ca channels play a critical role in induction of acrosome reaction in mammalian sperm. We determined the intracellular free Ca concentration in ejaculated goat sperm using a fluorescent, Ca-specific probe, Fura2/AM, after the suspension of sperm in KRB medium, capable of sustaining capacit...
متن کاملInhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm
Background: Normal sperm function depends on appropriate intracellular calcium (Cai2+) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by progesterone and intracellular alkalization. Herein, the interactive role of CatSper, Hv1 channels, and NOX5 enzyme on Cai2+ and ROS generatio...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2013
ISSN: 1479-6848
DOI: 10.1530/endoabs.32.p656